Karthik Mani hails from a family of musicians: his father, TAS Mani is a renowned percussionist of "The Karnataka College of Percussion", and his mother R.A.Ramamani is a reputed ground breaking Carnatic vocalist who has performed all over the world and has pioneered the genre of Carnatic-jazz fusion.

He has performed in various prestigious festivals in India, China, Spain, Germany, USA, Turkey, Malaysia, Morocco, UK, Bangkok, Thailand, Canada, Ireland, Sweden, Switzerland, Indonesia and Australia to name a few.

He has performed with musicians like Ustad Zakir Hussain, Ustad Hariharan, Dr. M. Balamurlikrishna, Padmashree Dr. L. Subramaniam, Padmashree Kadri Gopalnath, Shankar Mahadevan, Loy Mendonza, Louis Banks, Padmashree Kavita Krishnamurthy, Carnatic Maestro Mandolin U Sreenivas to name a few.

And international artists such as Kai Eckhardt, Ronan Guilfoyle, Okay Temiz, Ramesh Shotham, Mike Herting, African singer Mory Kante, Tunisian singer Dhafer Yousuf, Afro-Cuban percussionist Mokhtar Samba, Paul Shigihara, Lucas Niggli, Trombonist Nils Wogram, to name a few.

Karthik has worked extensively in the field of Traditional Indian dances, Contemporary dances, Movies, Folk Rock, Jazz, Carnatic, Hindustani, Advertisements, Percussion Ensembles, Theatres Plays, Bollywood projects and many more.

He is been performing concerts throughout India as well as abroad and has performed in various International Music Festivals all over the world.He is the first Indian percussionist to win the "Independent World Music Award" for World Fusion with "Lehera".